• Attention deficits resulting from TBI, including their nature, measurement, and pharmacologic and non-pharmacologic treatment
• Disorders of consciousness, including imaging correlates, clinical assessment, medical complications, long-term outcome and prognosis, treatment, and ethical issues.
• Functional recovery patterns and chronic deficits after severe TBI

Whyte J, Hart T, Vaccaro M, Grieb-Neff P, Risser A, Polansky M, Coslett HB: The effects of methylphenidate on attention deficits after traumatic brain injury: A multi-dimensional randomized controlled trial.  Am J Phys Med Rehabil, 83(6):401-420, 2004 PMID:15166683

Giacino JT, Whyte J, Bagiella E, et al: Placebo-controlled trial of amantadine for severe traumatic brain injury. NEJM, 366(9): 819-26, 2012 [* co-first authors] PMID:22375973

Rabinowitz AR, Hart T, Whyte J, Kim J.  Neuropsychological recovery trajectories in moderate to severe TBI: Influence of patient characteristics and diffuse axonal injury. J Int Neuropsychol Soc 24(3):237-246, 2018

• Treatment theory (how interventions result in functional change) and enablement theory (how various lower order impairments and limitations (e.g., limb weakness, memory impairment) predict more complex higher-order functions (e.g., social interaction, employment)
• Rehabilitation-specific challenges to translational research
• A theory-based framework to specify rehabilitation treatments with respect to their known or hypothesized active ingredients

Whyte J. The contributions of treatment theory and enablement theory to rehabilitation research and practice. Arch Phys Med Rehabil, 95(Suppl 1):S17-S23, 2014 PMID:24370321

Whyte J, Gordon W, Gonzalez-Rothi, L: A phased developmental approach to neurorehabilitation research: The science of knowledge building.  Arch Phys Med Rehabil, 90(11 Suppl 1):S3-10, 2009 PMID:19892072

Zanca J, Turkstra LS, Chen C. . . Whyte J, et al: Advancing rehabilitation practice through improved specification of interventions. Arch Phys Med Rehabil 100:164-171, 2019

• Co-director, with Michael Boninger, MD, at the University of Pittsburgh, the NIH-funded Rehabilitation Medicine Scientist Training Program, which supports young physicians seeking research careers in rehabilitation in developing rigorous mentored career development plans and obtaining funding for their proposed training.

Whyte J, Boninger M, Helkowski W, Braddom-Ritzler, C: The Rehabilitation Medicine Scientist Training Program: Impact and lessons learned.  Am J Phys Med Rehabil, 88(3): 169 – 179, 2009 PMID:19847126

For a full list of Dr. Whyte’s published research, click here.

Avants, B. B., Duda, J. T., Kim, J., Zhang, H., Pluta, J., Gee, J. C., & Whyte, J. (2008). Multivariate analysis of structural and diffusion imaging in traumatic brain injury. Acad Radio;, 15(11), 1360-1375. PMID:18995188

Baguley, I., Perkes, I., Fernandez-Ortega, J. F., Rabinstein, A. A., Dolce, G., Hendricks, H. T., & et, a. l. (2014). Paroxysmal sympathetic hyperactivity after acquired brain injury: consensus on conceptual definition, nomenclature, and diagnostic criteria. J  Neurotrauma, 31(17), 1515-1520. PMID:24731076

Barker, M. D., Whyte, J., Pretz, C. R., Sherer, M., Temkin, N., Hammond, F. M., . . . Novack, T. (2014). Application and clinical utility of the Glasgow Coma Scale over time: A study employing NIDRR traumatic brain injury model systems database. J Head Trama Rehabil, 29(5), 400-406. PMID:23535391

Bernabeu, M., Laxe, S., Lopez, R., Stucki, G., Ward, A., Barnes, M., . . . Cieza, A. (2009). Developing core sets for ;persons with traumatic brain injury based o nthe international classification of functioning, disability, and health. Neurorehabil Neural Repair, 23(5), 464-467. PMID:19221004

Boninger, M. L., Whyte, J., J, D., Zafonte, R., & Chan, L. (2009). Building a research program in physical medicine and rehabilitation. Am J Phys Med Rehabil, 88(8), 659-666. PMID:19620832

Buxbaum, L. J., Ferraro, M., Whyte, J., Gershkoff, A., & Coslett, H. B. (2007). Amantadine treatment of hemispatial neglect: A double-blind, placebo-controlled study. Am J Phys Med Rehabil, 86(7), 527-537. PMID:17581287

Chatelle, C., Majerus, S., Whyte, J., Laureys, S., & Schnakers, C. (2012). A sensitive scale to asess nociceptive pain with disorders of consciousness. J Neurol Neurosurg Psychiat, 83, 1233-1237. doi: 10.1136/jnnp-2012-302987 PMID:22906615

Chatelle, C., Thibaut, A., Whyte, J., DeVal, M. D., Laureys, S., & Schnakers, C. (2014). Pain issues in disorders of consciousness. Brain Injury, 28(9), 1202-1208. PMID:25099024

Cicerone, K. D., Levin, H., Malec, J. F., Stuss, D., & Whyte, J. (2006). Cognitive rehabilitation interventions for executive function: moving from bench to bedside in patients with traumatic brain injury. J Cog Neurosci, 18(7), 1212-1222. PMID:16839293

Clohan, D. B., Durkin, E. M., Hammel, J., Murray, P., Whyte, J., Dijkers, M., . . . Worsowicz, G. (2007). Post-acute rehabilitation research and policy recommendations. Arch Phys Med Rehabil, 88(11), 1535-1541. PMID:17964901

Dams-O’Connor, K., Cuthbert, J., Whyte, J., Corrigan, J., Faul, M., & Harrison-Felix, C. (2013). Traumatic brain injury among older adults at Level I and II trauma centers. J  Neurotrauma, 30(24), 2001-2013. PMID:23962046

Dijkers, M., Hart, T., Tsaousides, T., Whyte, J., & Zanca, J. (2014). Treatment taxonomy for rehabilitation: Past, present and prospects. Arch Phys Med Rehabil, 95((Suppl 1)), S6 – S16. PMID:24370326

Dijkers, M., Hart, T., Whyte, J., Zanca, J., Packel, A., & Tsaousides, T. (2014). Rehabilitation treatment taxonomy: Implications and continuations. Arch Phys Med Rehabil, 95((Suppl 1)), S45 – S54. PMID:24370324

Giacino, J., & Whyte, J. (2005). The vegetative and minimally conscious states: current knowledge and remaining questions. J Head Trama Rehabil, 20(1), 30-50. PMID:15668569

Giacino, J. T., Katz, D. I., & Whyte, J. (2013). Neurorehabilitation in disorders of consciousness. Semin Neurol, 33(2), 142-156. PMID:23888398

Giacino*, J. T., Whyte*, J., Bagiella, E., Kalmar, K., Childs, N., Khademi, A., . . . Sherer, M. (2012). Placebo-controlled trial of amantadine for severe traumatic brain injury. NEJM, 366(9), 819-826 [* co-first authors] PMID:22375973

Hamilton, R. H., Coslett, H. B., Buxbaum, L. J., Whyte, J., Farne, A., Frassinetti, F., & Ferraro, M. K. (2007). Inconsistency of performance on neglect subtype tests following acute right hemisphere stroke. J Int Neuropsychol  Soc, 14, 23-32. PMID:18078528

Hart, T., Brockway, J. A., Whyte, J., Bell, K. R., Neuberger, S., & Chevoneva, I. (2013). Analyzing the ingredients of a telephone counseling intervention for traumatic brain injury. Disabil, 35(19), 1668-1675. doi: 10.3109/09638288.2012.7514131  PMID:23336123

Hart, T., Dijkers, M., Fraser, R., Cicerone, K., Bogner, J. A., Whyte, J., . . . Waldron, B. (2006). Vocational services for traumatic brain injury: treatment definition and diversity within model systems of care. J Head Trauma Rehabil, 21(6), 467-482. PMID:17122678

Hart, T., Dijkers, M., Whyte, J., Braden, C., Trott, C., & Fraser, R. (2010). Vocational interventions and supports following job placement for persons with traumatic brain injury. J Voc Rehabil, 32(3), 135-150.

Hart, T., Kozlowski, A., Whyte, J., Poulsen, I., Kristensen, K., Nordenbo, A., & Heinemann, A. W. (2014). Functional recovery after severe traumatic brain injury. Arch Phys Med Rehabil, 95, 2103-2110. PMID:25010537

Hart, T., Sherer, M., Temkin, N., Whyte, J., Dikmen, S., Heinemann, A. W., & Bell, K. (2010). Participant-proxy agreement on objective and subjective aspects of societal participation following traumatic brain injury. J Head Trama Rehabil, 25(5), 339-348. PMID:20042981

Hart, T., Tsaousides, T., Zanca, J., Whyte, J., Packel, A., Ferraro, M., & Dijkers, M. (2014). Toward a theory-driven classification of rehabilitation treatments. Arch Phys Med Rehabil, 95(Suppl 1), S33 – S44. PMID:24370323

Hart, T., Whyte, J., Ellis, C., & Chervoneva, I. (2009). Construct validity of an Attention Rating Scale for traumatic brain injury. Neuropsychology, 23(6), 729-735. PMID:19899831

Hart, T., Whyte, J., Kim, J., & Vaccaro, M. (2005). Executive function and self-awareness of “real-world” behavior and attention deficits following traumatic brain injury. J Head Trauma Rehabil, 20(4), 333-347. PMID:16030440

Hart, T., Whyte, J., Millis, S., Bode, R., Malec, J. F., Hammond, F. M., . . . Hammond, F. (2006). Dimensions of disordered attention in traumatic brain injury: further validation of the Moss Attention Rating Scale. Arch Phys Med Rehabil, 87(5), 647-655. doi: S0003-9993(06)00099-2 [pii]10.1016/j.apmr.2006.01.016 PMID:16635627

Hart, T., Whyte, J., Polansky, M., Kersey-Matusiak, G., & Fidler-Sheppard, R. (2005). Community outcomes following traumatic brain injury: Impact of race and pre-injury status. J Head Trama Rehabil, 20(2), 158-172. PMID:15803039

Johnston, M. V., Sherer, M., & Whyte, J. (2006). Applying evidence standards to rehabilitation research. Am J Phys Med Rehabil, 85(4), 292-309. PMID:16554683

Kim, H., Whyte, J., Patel, S., Avants, B., Europa, E., Wang, J., . . . Detre, J. A. (2010). Resting cerebal blood flow  alterations in chronic traumatic brain injury: An arterial spin labeling perfusion fMRI study. J Neurotrauma, 27(8), 1399-1411. PMID:20528163

Kim, J., Avants, B., Patel, S., Whyte, J., Coslett, B. H., Pluta, J., . . . Gee, J. C. (2008). Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry study. Neuroimage, 39(3), 1014-1026. PMID:17999940

Kim, J., Avants, B., Whyte, J., & Gee, J. (2013). Methodological considerations in longitudinal morphometry of traumatic brain injury. Frontiers Hum Neurosci, 7, 52. doi: 01.3389/fnhum.2013.00052 PMID:23549059

Kim, J., Parker, D., Whyte, J., Hart, T., Pluta, J., Ingalhalikar, M., . . . Verma, R. (2014). Disrupted structural connectome is associated with both psychometric and real-world neuropsychological deficits in diffuse traumatic brain injury. J Int Neuropsychol  Soc, 20(9), 887-896. PMID:25287217

Kim, J., Whyte, J., Hart, T., Vaccaro, M., Polansky, M., & Coslett, H. B. (2005). Executive function as a predictor of inattentive behavior after traumatic brain injury. J Int Neuropsychol  Soc, 11(4), 434-445. PMID:16209424

Kim, J., Whyte, J., Patel, S., Europa, E., Slattery, J., Coslett, H. B., & Detre, J. A. (2012). A perfusion fMRI study of the neural correlates of sustained-attention and working-memory deficits in chronic traumatic brain injury. Neurorehabil Neural Repair, 26(7), 870-880. PMID:22357634

Kim, J., Whyte, J., Patel, S., Europa, E., Wang, J., Coslett, H. B., & Detre, J. (2012). Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: A perfusion fMRI study. Psychopharm, 222(1), 47-57. PMID:22203319

Kim, J., Whyte, J., Wang, J., Rao, H., Tang, K. Z., & Detre, J. A. (2006). Continuous ASL perfusion fMRI investigation of higher cognition: quantification of tonic CBF changes during sustained attention and working memory tasks. Neuroimage, 31(1), 376-385. PMID:16427324

Lehtonen, S., Stringer, A. Y., Millis, S., Boake, C., Englander, J., Hart, T., . . . Whyte, J. (2005). Neuropsychological outcome and community re-integration following traumatic brain injury: the impact of frontal and non-frontal lesions. Brain Injury, 19(4), 239-256. PMID:15832870

Malec, J. F. H., F M, Giacino, J. T., Whyte, J., & Wright, J. (2012). Structured interview to improve the relilability and psychometric integrity of the disability rating scale Arch Phys Med Rehabil, 93(9), 1603-1608. PMID:22510680

Marquez de la Plata, C. D., Hart, T., Hammond, F. M., Frol, A. B., Hudak, A., Harper, C. R., . . . Diaz-Arrastia, R. (2008). Impact of age on long-term recovery from traumatic brain injury. Arch Phys Med Rehabil, 89(5), 896-903. PMID:18452739

Martin, R. T., & Whyte, J. (2007). The effects of methylphenidate on command following and yes/no communication in persons with severe disorders of consciousness: a meta-analysis of N-of-1 studies. Am J Phys Med Rehabil, 86(8), 613-620. PMID:17667191

Mayer, N., Whyte, J., Wannstedt, G., & Ellis, C. (2008). Comparative Impact of Two Botulinum Toxin Injection Techniques for Elbow Flexor Hypertonia. Arch Phys Med Rehabil, 89(5), 982-987. PMID:18452749

Morgenroth, D. C., Boninger, M. L., Czerniecki, J. M., Houtrow, A. J., Robinson, L., Sowa, G., & Whyte, J. (2012). Academic physiatry: vignettes of rewarding careers. PM&R, 4(12), 923-927. doi: 10.1016/j.pmrj.2012.10.010 PMID:23245660

Nakase-Richardson, R., Tran, J., Cifu, D., Barnett, S. D., Horn, L. J., Greenwald, B. D., . . . Giacino, J. T. (2013). Do rehospitalization rates differ among severity levels in the NIDRR Traumatic Brain Injury Model Systems Program? Arch Phys Med Rehabil, 94(10), 1884-1890. PMID:23770278

Nakase-Richardson, R., Whyte, J, Giacino, J. T., Pavawalla, S., Barnett, S. D., Yablon, S. A., . . . Walker, W. (2012). Longitudinal outcome of patients with disordered consciousness in the NIDRR TBI Model Systems Programs. J Neurotrauma, 29(1), 59-65. PMID:21663544

Ratcliff, J. J., Greenspan, A. L., Goldstein, F. C., Stringer, A. Y., Bushnik, T., Hammond, F. M., . . . Wright, D. (2007). Gender and traumatic brain injury: do the sexes fare differently? Brain Injury, 21(10), 1023-1030. PMID:17891564

Schwartz, M. F., Brecher, A. R., Whyte, J., & Klein, M. G. (2005). A patient registry for cognitive rehabilitation research: a strategy for balancing patients’ privacy rights with researchers’ need for access. Arch Phys Med Rehabil, 86(9), 1807-1814. PMID:16181947

Seel, R. T., Sherer, M., Whyte, J., Katz, D. I., Giacino, J. T., Shapiro, A., . . . Zasler, N. (2010). Assessment scales for disorders of consciousness: evidence-based recommendations for clinical practice and research. Arch Phys Med Rehabil, 91(12), 1795-1813. PMID:21112421

Segal, M. E., Goodman, P. H., Goldstein, R., Hauck, W., Whyte, J., Graham, J. W., . . . Hammond, F. M. (2006). The accuracy of artificial neural networks in predicting long-term outcome after traumatic brain injury. J Head Trama Rehabil, 21(4), 298-314. PMID:16915007

Sherer, M., Hart, T., Whyte, J., Nick, T. G., & Yablon, S. A. (2005). Neuroanatomic basis of impaired self-awareness after traumatic brain injury: findings from early computed tomography. J Head Trama Rehabil, 20(4), 287 – 300. PMID:116030437

Tustison, N. J., Avants, B. B., Cook, P. A., Kim, J., Whyte, J., Gee, J. C., & Stone, J. R. (2012). Logical circularity in voxel-based analysis: Normalization strategy may induce statistical bias. Human Brain Mapping. doi: 10.1002/hbm.22211 PMID:23151955

Vaccaro, M., Hart, T., Whyte, J., & Buchhofer, R. (2007). Internet use and interest among individuals with traumatic brain injury:  A consumer survey. Disability and Rehabil, 2(2), 85-95. PMID:19263543

Warden, D., Gordon, B., McAllister, T., Silver, J., Barth, J., Bruns, J., . . . Zitnay, G. (2006). Guidelines for the pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury. J Neurotrauma, 23(10), 1468 – 1501. PMID:17020483

Whiteneck, G. G., Charlifue, S. W., Gerhart, K. A., Overholser, J. D., & Richardson, G. N. (1992). Quantifying handicap: a new measure of long-term rehabilitation outcomes. Arch Phys Med Rehabil, 73(6), 519-526. doi: 0003-9993(92)90185-Y [pii] PMID:1622299

Whyte, J. (2005). Training and retention of rehabilitation researchers. Am J Phys Med Rehabil, 84, 969 PMID:16327413

Whyte, J. (2006). Using treatment theory to refine the designs of brain injury rehabilitation treatment effectiveness studies. J Head Trama Rehabil, 21(2), 99-106. PMID:16569984

Whyte, J. (2007). Treatments to enhance recovery from the vegetative and minimally conscious states: ethical issues surrounding efficacy studies. Am J Phys Med Rehabil, 86(2), 86-92. PMID:17251691

Whyte, J. (2008). A grand unified theory of rehabilitation (We Wish!)”. The 57th John Stanley Coulter Memorial Lecture. Archives of Physical Medicine & Rehabilitation, 89(2), 203-209. PMID:18226642

Whyte, J. (2009). Directions in brain injury research: From concept to clinical implementation. Neuropsychol Rehabil, 19(6), 807-823. PMID:19548176

Whyte, J. (2010). Pharmacologic treatment of cognitive and behavioral sequelae of traumatic brain injury: practicing in the absence of strong evidence. Eur J Phys Rehabil Med, 46(4), 557-562. PMID:21224788

Whyte, J. (2013). Complete locked-in syndrome: what’s in a name? Comment on J Head Trauma Rehabil,  28(2), 144 – 145. PMID:22935570

Whyte, J. (2014a). The contributions of treatment theory and enablement theory to rehabilitation research and practice. Arch Phys Med Rehabil, 95((Suppl 1)), S17 – S23. PMID:24370321

Whyte, J. (2014b). Disorders of Consciousness: The Changing Landscape of Treatment. Neurology. Neurology, 82(13), 1106-1107. PMID:24574547

Whyte, J., & Barrett, A. M. (2012). Advancing the evidence base of rehabilitation treatments: A developmental approach. Arch Phys Med Rehabil, 93(supp; 8), S101-S110. PMID:22683206

Whyte, J., Boninger, M., Helkowski, W., & Braddom-Ritzler, C. (2009). The Rehabilitation Medicine Scientist Training Program: Impact and lessons learned. American Journal of Physical Medicine & Rehabilitation, 88(3), 169-179. PMID:19847126

Whyte, J., Dijkers, M., Hart, T., Zanca, J., Packel, A., Ferraro, M., & Tsaousides, T. (2014). Development of a theory-driven rehabilitation treatment taxonomy: conceptual issues. Arch Phys Med Rehabil, 95(Suppl 1), S24 – S32. PMID:24370322

Whyte, J., Gordon, W., & Gonzalez-Rothi, L. (2009). A phased developmental approach to neurorehabilitation research: The science of knowledge building. Arch Phys Med Rehabil, 90(11 Suppl 1), S3-S10. PMID:19892072

Whyte, J., Gossiers, O., Chervoneva, I., DiPasquale, M. C., Giacino, J., Kalmar, K., . . . Eifert, B. (2009). Predictors of short-term outcome in brain-injured patients with disorders of consciousness. Prog Brain Res, 177, 63-72. PMID:19818895

Whyte, J., Grieb-Neff, P., Gantz, C., & Polansky, M. (2007). Measuring sustained attention after traumatic brain injury: differences in key findings from the sustained attention to response task (SART). Neuropsychologia, 44(10), 2007-2014. PMID:16682059

Whyte, J., Hart, T., Ellis, C., & Chervoneva, I. (2008). The Moss Attention Rating Scale for traumatic brain injury: Further explorations of reliability and sensitivity to change. Archives of Physical Medicine and Rehabilitation, 89, 966-973. PMID:18452747

Whyte, J., Katz, D., Long, D., DiPasquale, M. C., Polansky, M., Kalmar, K., . . . Eifert, B. (2005). Predictors of outcome and effect of psychoactive medications in prolonged posttraumatic disorders of consciousness: A multicenter study. Arch Phys Med Rehabil, 86(3), 453 – 462. PMID:15759228

Whyte, J., & Myers, R. (2009). Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: A preliminary placebo controlled trial. Am J Phys Med Rehabil, 88(5), 410-418. PMID:19620954

Whyte, J., & Nakase-Richardson, R. Disorders of consciousness: Outcomes, comorbidities, and care needs. Arch Phys Med Rehabil, 94(10), 1851-1854. doi: 10.1016/J.APMR.2013.07.003 PMID:23856152

Whyte, J., Nakase-Richardson, R., Hammond, F. M., McNamee, S., Giacino, J. T., Kalmar, K., . . . Horn, L. J. (2013). Functional outcomes in traumatic disorders or consciousness: 5-year outcomes from the NIDRR traumatic brain injury model systems. Arch Phys Med Rehabil, 94(10), 1855-1860. PMID:23732164

Whyte, J., Nordenbo, A. M., Kalmar, K., Merges, B., Bagiella, E., Chang, H., . . . Giacino, J. (2013). Medical complications during inpatient rehabilitation among patients with traumatic disorders of consciousness. Arch Phys Med Rehabil, 94(10), 1877-1883. PMID:23735519

Whyte, J., Rajan, R., Rosenbaum, A., Katz, D., Kalmar, K., Seel, R., . . . Kaelin, D. Zolpidem and Restoration of Consciousness. Am J Phys Med Rehabil, 93, 101-113. PMID:24434886

Whyte, J., Vaccaro, M., Grieb-Neff, P., Polansky, M., & Coslett, H. B. (2008). The effects of bromocriptine on attention deficits after traumatic brain injury: A Placebo-controlled pilot study. Amer J Phys Med Rehabil, 87(2), 85-99. PMID:18209510

Whyte, J., Vasterling, J., & Manley, G. T. (2010). Common data elements for research on traumatic brain injury and psychological health: Current status and future development. Archives of Physical Medicine & Rehabilitation, 91(11), 1692-1696. PMID:21044713